Onderzoek naar insuline-actie en de toekomst van diabetesbehandeling: de Banting-medaille van 2017 voor wetenschappelijke prestatiecollege.

Diabetes is toe te schrijven aan gemengde afwijkingen in de insulineproductie en beweging. De pathofysiologie van deze defecten is uitgebreid bestudeerd en redelijkerwijs begrepen.

Hun oorzaken zijn ongrijpbaar en hun manifestaties zijn pleiotroop, waarschijnlijk als gevolg van het drievoudige risico van genen, omgeving en levensstijl. Behandelaars brengen, zodra ze zich beperken tot monotherapie met secretagogen of insuline, nu geavanceerde mengsels van kostbare behandelingen die de ontwikkeling afremmen, maar die in wezen de onderliggende oorzaken van de ziekte niet veranderen.

Naarmate de vooruitgang in ons begrip van insulinebeweging en β-celfalen een essentieel stadium bereikt, put ik hier uit lessen die zijn gerealiseerd uit onze analyse van insulineregulatie van genexpressie en pancreatische β-celdifferentiatie om de vraag af te handelen van hoe we deze spannende biologie zullen vertalen in op mechanismen gebaseerde interventies om het beloop van diabetes om te keren.

 Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture.
Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture.

Analyse van diabetes mellitus-determinanten in Indonesië: een onderzoek uit het Indonesische basisgezondheidsonderzoek 2013.

ACHTERGROND diabetes mellitus is een stille moordenaar. De prevalentie en indruk op welzijnsrekeningen nemen toe van 12 maanden tot 12 maanden.

Dit onderzoekt doelen om de eigenschappen en de bedreigingscomponenten te analyseren die een effect hebben op diabetes mellitus in Indonesië. METHODE Dit is een cross-sectioneel onderzoek. Gegevens zijn verkregen uit het Basisgezondheidsonderzoek (RISKESDAS) in 2013.

De monsters zijn mensen van ≥15 jaar oud, bij wie de nuchtere bloedglucose en 2 uur bloedglucose na het opleggen zijn gemeten. Voor dit onderzoek zijn 38.052 personen gekozen. De variabelen leeftijd, geslachtsgemeenschap, burgerlijke staat, scholingsstadium, beroepsstatus, woonruimte, regionale status, hypertensie, gewichtsproblemen, rookgedrag en dyslipidemie worden geanalyseerd als bedreigingscomponenten voor diabetes mellitus.

Diabetes (Type 2) Exosome RNA

P241-DB2 - Ask for price

Human Type 1 Diabetes Leukopak

ABC-TC4310 1 pack Ask for price
Description: RI dependent diabetes, or Type 1 Diabetes is caused by the pancreas producing little to no RI.

Human Type 2 Diabetes Leukopak

ABC-TC4311 1 pack Ask for price
Description: Non-RI dependent diabetes, or Type 2 Diabetes, is characterized by hyperglycemia that is caused by a combination of RI resistance and the body's s inability to compensate by producing more RI.

Single Donor Human Diabetes Serum

ISERSDIB each
EUR 209
Description: Single Donor Human Diabetes Serum

Human Diabetes Lung Tissue Lysate

IHULGDIBTL100UG each
EUR 1413
Description: Human Diabetes Lung Tissue Lysate

Single Donor Human Diabetes Plasma

IPLASDIB each
EUR 209
Description: Single Donor Human Diabetes Plasma

Human Diabetes Colon Tissue Lysate

IHUCLNDIBTL100UG each
EUR 1413
Description: Human Diabetes Colon Tissue Lysate

Human Diabetes Ileum Tissue Lysate

IHUILMDIBTL100UG each
EUR 1413
Description: Human Diabetes Ileum Tissue Lysate

Human Type I Diabetes PB Plasma

ABC-TC4264 1 vial Ask for price
Description: Type I Diabetes peripheral blood plasma is obtained by centrifugation of the Type I Diabetes PB. This product has a diminished number of cells and platelets. Fresh Diabetic Type I PB plasma is available upon request.

Human Type II Diabetes PB Plasma

ABC-TC4266 1 vial Ask for price
Description: Type II Diabetes peripheral blood plasma is obtained by centrifugation of the Type II Diabetes PB. This product has a diminished number of cells and platelets. Fresh Diabetic Type II PB plasma is available upon request.

Human Diabetes Stomach Tissue Lysate

IHUSTDIBTL100UG each
EUR 1413
Description: Human Diabetes Stomach Tissue Lysate

Human Diabetes Jejunum Tissue Lysate

IHUJEJDIBTL100UG each
EUR 1413
Description: Human Diabetes Jejunum Tissue Lysate

Human Diabetes Pancreas Tissue Lysate

IHUPCSDIBTL100UG each
EUR 1413
Description: Human Diabetes Pancreas Tissue Lysate

Human Diabetes Duodenum Tissue Lysate

IHUDUODIBTL100UG each
EUR 1413
Description: Human Diabetes Duodenum Tissue Lysate

Human Diabetes Esophagus Tissue Lysate

IHUESOPDIBTL100UG each
EUR 1413
Description: Human Diabetes Esophagus Tissue Lysate

Human Muscle Myoblasts, Diabetes Type I

ABC-TC3956 1 vial Ask for price
Description: Diabetic Type I and Type II HSMM-Human Skeletal Muscle Myoblasts are isolated from donors diagnosed with either Diabetes Type I or Diabetes Type II. Additional donor information is available by contacting Scientific Support.

Human Muscle Myoblasts, Diabetes Type II

ABC-TC3957 1 vial Ask for price
Description: Diabetic Type I and Type II HSMM-Human Skeletal Muscle Myoblasts are isolated from donors diagnosed with either Diabetes Type I or Diabetes Type II. Additional donor information is available by contacting Scientific Support.

Single Donor HumanType I Diabetes Semen

IRHUSSMDIBTI1 each
EUR 842
Description: Single Donor HumanType I Diabetes Semen

Human Diabetes AdiposeVisceral Tissue Lysate

IHUADPTVDIBTL100UG each
EUR 2663
Description: Human Diabetes AdiposeVisceral Tissue Lysate

Single Donor Human Type II Diabetes Semen

IRHUSMSDIBTII1ML each
EUR 842
Description: Single Donor Human Type II Diabetes Semen

Single Donor Human Type I Diabetes Urine

IRHUURESDIBTI250ML each
EUR 1063
Description: Single Donor Human Type I Diabetes Urine

Single Donor Human Type I Diabetes Urine

IRHUURESDIBTI50ML each
EUR 439
Description: Single Donor Human Type I Diabetes Urine

Single Donor Human Type II Diabetes Urine

IRHUURESDIBTII250ML each
EUR 1063
Description: Single Donor Human Type II Diabetes Urine

Single Donor Human Type II Diabetes Urine

IRHUURESDIBTII50ML each
EUR 439
Description: Single Donor Human Type II Diabetes Urine

Human Diabetes Skeletal Muscle Tissue Lysate

IHUSKMDIBTL100UG each
EUR 1413
Description: Human Diabetes Skeletal Muscle Tissue Lysate

HighQC™ Human IPS Cell (Type 2 Diabetes)

ABC-SC0005T 1 vial Ask for price
Description: Induced Pluriopotent Stem Cells (iPSCs) are a type of pluripotent stem cells that can be derived directly from adult somatic cells . The derived iPSCs can propagate indefinitely, as well as give rise to other cell types in the body. iPS cells, thus, hold great promise in the field of regenerative medicine by representing a single source of cells that could be used to replace those damaged/diseased cells.

Human Diabetes AdiposeSubcutaneous Tissue Lysate

IHUADPTSDIBTL100UG each
EUR 2663
Description: Human Diabetes AdiposeSubcutaneous Tissue Lysate

Human Diabetes Pancreas Lysate Membrane Fraction

IHUPCSDIBTLM100UG each
EUR 1199
Description: Human Diabetes Pancreas Lysate Membrane Fraction

Human Diabetes Skeletal Muscle Lysate Membrane Fraction

IHUSKMDIBTLM100UG each
EUR 1199
Description: Human Diabetes Skeletal Muscle Lysate Membrane Fraction

Human Type I Diabetes Peripheral Blood Mononuclear Cells

ABC-TC4263 1 vial Ask for price
Description: Peripheral blood mononuclear cells are isolated from Type I Diabetes peripheral blood by diluting the whole blood with PBS and using gradient separation techniques. After centrifugation,the mononuclear cell layer is collected. Mononuclear Cells can be processed further to isolate subpopulations. Fresh Diabetic Type I PBMCs is available upon request.

Human Type II Diabetes Peripheral Blood Mononuclear Cells

ABC-TC4265 1 vial Ask for price
Description: Human Peripheral Blood Mononuclear Cells are available as positive and negative controls for T-cell monitoring in ELISPOT, ELISA, cytokine bead array, tetramer/pentamer, and flow cytometry assays. A peripheral blood mononuclear cell is defined as any blood cell with a round nucleus. These blood cells are a critical component in the immune system to fight infection and adapt to intruders. The lymphocyte population consists of CD4+ and CD8+ T cells, B cells and Natural Killer cells, CD14+ Monocytes, and Basophils/Neutrophils/Eosinophils/Dendritic cells. These cells are often extracted from whole blood or from leukopacks using ficoll, a hydrophilic polysaccharide that separates layers of blood, with monocytes and lymphocytes forming a buffy coat under a layer of plasma.Samples from each donor are tested via PCR to confirm non-reactivity. Peripheral blood mononuclear cells are isolated from Type II Diabetes peripheral blood by diluting the whole blood with PBS and using gradient separation techniques. After centrifugation,the mononuclear cell layer is collected. Mononuclear Cells can be processed further to isolate subpopulations. Fresh Diabetic Type II PBMCs is available upon request.

HighQC™ Human IPS Cell (Episomal/ Diabetes Type II/ Adipose)

ABC-SC0011T 1 vial Ask for price
Description: Gentaur offers human iPS cell lines derived from PBMCs, dermal fibroblasts, or adipose tissue of patients with Parkinson's Disease (PD) and Diabetes II. These iPS cells are established from a single clone and expanded in feeder-free conditions.

HighQC™ Induced Pluripotent Stem Cell, From Diabetes (mellitus)

ABC-SC0241 1 vial Ask for price
Description: Diabetes (mellitus), Primary cell type: Fibroblast, Unknown vector detectable; Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

HighQC™ Human IPS Cell (IPSC From PBMC/ Diabetes Type II/ Episomal)

ABC-SC0009T 1 vial Ask for price
Description: Gentaur offers human iPS cell lines derived from PBMCs, dermal fibroblasts, or adipose tissue of patients with Parkinson's Disease (PD) and Diabetes II. These iPS cells are established from a single clone and expanded in feeder-free conditions.

Rrad (GFP-tagged) - Mouse Ras-related associated with diabetes (Rrad)

MG204351 10 µg Ask for price

Rrad (untagged) - Mouse Ras-related associated with diabetes (Rrad), (10ug)

MC203288 10 µg Ask for price

Rrad (untagged ORF) - Rat Ras-related associated with diabetes (Rrad), (10 ug)

RN208148 10 µg Ask for price

HighQC™ Human IPS Cell (IPSC From Fibroblast/ Diabetes Type II/ Episomal)

ABC-SC0010T 1 vial Ask for price
Description: Gentaur is is proud to offer human iPS cell lines derived from the human dermal fibroblasts from patients with Type 2 Diabetes (T2D). The pertinent donor information is available upon request. These iPS cells are established from a single clone and expanded in feeder-free conditions. Normal human iPS cell lines are also available as separate products . We also provide custom iPSC generation and iPSC differentiation services to meet your needs.

Rrad (Myc-DDK-tagged) - Mouse Ras-related associated with diabetes (Rrad)

MR204351 10 µg Ask for price

Rrad (Myc-DDK-tagged ORF) - Rat Ras-related associated with diabetes (Rrad), (10 ug)

RR208148 10 µg Ask for price

HighQC™ Human Bone Marrow Derived Mesenchymal Stem Cell/ Type II Diabetes Patient

ABC-SC0027T 1 vial Ask for price
Description: Human MSCs (Bone Marrow Derived) from a single adult donor clinically diagnosed with Type II Diabetes. The MSCs are compatible with our MSC Expansion Medium for Bone Marrow Derived MSCs.All of the cells provided are tested and are negative for HIV-1, HIV-2, Hepatitis B and Hepatitis C as detected by PCR. The cells are confirmed to be negative for mycoplasma and other detectable microbial contamination.

RRAD (untagged)-Human Ras-related associated with diabetes (RRAD), transcript variant 2

SC117559 10 µg Ask for price

RRAD (untagged)-Human Ras-related associated with diabetes (RRAD), transcript variant 1

SC322965 10 µg Ask for price

Lenti ORF clone of Rrad (mGFP-tagged) - Mouse Ras-related associated with diabetes (Rrad)

MR204351L4 10 µg Ask for price

RRAD (GFP-tagged) - Human Ras-related associated with diabetes (RRAD), transcript variant 2

RG202927 10 µg Ask for price

RRAD (GFP-tagged) - Human Ras-related associated with diabetes (RRAD), transcript variant 1

RG225433 10 µg Ask for price

Lenti ORF clone of Rrad (Myc-DDK-tagged) - Mouse Ras-related associated with diabetes (Rrad)

MR204351L3 10 µg Ask for price

Lenti ORF clone of Rrad (mGFP-tagged ORF) - Rat Ras-related associated with diabetes (Rrad), (10 ug)

RR208148L4 10 µg Ask for price

RRAD (Myc-DDK-tagged)-Human Ras-related associated with diabetes (RRAD), transcript variant 2

RC202927 10 µg Ask for price

RRAD (Myc-DDK-tagged)-Human Ras-related associated with diabetes (RRAD), transcript variant 1

RC225433 10 µg Ask for price

Lenti ORF clone of Rrad (Myc-DDK-tagged ORF) - Rat Ras-related associated with diabetes (Rrad), (10 ug)

RR208148L3 10 µg Ask for price

Lenti ORF clone of Human Ras-related associated with diabetes (RRAD), transcript variant 2, mGFP tagged

RC202927L4 10 µg Ask for price

Lenti ORF clone of Human Ras-related associated with diabetes (RRAD), transcript variant 1, mGFP tagged

RC225433L2 10 µg Ask for price

Lenti ORF clone of Human Ras-related associated with diabetes (RRAD), transcript variant 1, mGFP tagged

RC225433L4 10 µg Ask for price

Lenti ORF particles, Rrad (GFP-tagged) - Mouse Ras-related associated with diabetes (Rrad), 200ul, >10^7 TU/mL

MR204351L4V 200 µl Ask for price

Lenti ORF particles, Rrad (GFP-tagged ORF) - Rat Ras-related associated with diabetes (Rrad), 200ul, >10^7 TU/mL

RR208148L4V 200 µl Ask for price

Lenti ORF clone of Human Ras-related associated with diabetes (RRAD), transcript variant 2, Myc-DDK-tagged

RC202927L3 10 µg Ask for price

Lenti ORF clone of Human Ras-related associated with diabetes (RRAD), transcript variant 1, Myc-DDK-tagged

RC225433L1 10 µg Ask for price

Lenti ORF clone of Human Ras-related associated with diabetes (RRAD), transcript variant 1, Myc-DDK-tagged

RC225433L3 10 µg Ask for price

3`UTR clone of Ras-related associated with diabetes (RRAD) transcript variant 2 for miRNA target validation

SC205326 10 µg Ask for price

3`UTR clone of Ras-related associated with diabetes (RRAD) transcript variant 1 for miRNA target validation

SC205328 10 µg Ask for price

Lenti ORF particles, Rrad (Myc-DDK-tagged) - Mouse Ras-related associated with diabetes (Rrad), 200ul, >10^7 TU/mL

MR204351L3V 200 µl Ask for price

Lenti ORF particles, Rrad (Myc-DDK-tagged ORF) - Rat Ras-related associated with diabetes (Rrad), 200ul, >10^7 TU/mL

RR208148L3V 200 µl Ask for price

Lenti ORF particles, RRAD (mGFP-tagged) - Human Ras-related associated with diabetes (RRAD), transcript variant 2, 200ul, >10^7 TU/mL

RC202927L4V 200 µl Ask for price

Lenti ORF particles, RRAD (mGFP-tagged) - Human Ras-related associated with diabetes (RRAD), transcript variant 1, 200ul, >10^7 TU/mL

RC225433L2V 200 µl Ask for price

Lenti ORF particles, RRAD (mGFP-tagged) - Human Ras-related associated with diabetes (RRAD), transcript variant 1, 200ul, >10^7 TU/mL

RC225433L4V 200 µl Ask for price

Lenti ORF particles, RRAD (Myc-DDK tagged) - Human Ras-related associated with diabetes (RRAD), transcript variant 2, 200ul, >10^7 TU/mL

RC202927L3V 200 µl Ask for price

Lenti ORF particles, RRAD (Myc-DDK tagged) - Human Ras-related associated with diabetes (RRAD), transcript variant 1, 200ul, >10^7 TU/mL

RC225433L1V 200 µl Ask for price

Lenti ORF particles, RRAD (Myc-DDK tagged) - Human Ras-related associated with diabetes (RRAD), transcript variant 1, 200ul, >10^7 TU/mL

RC225433L3V 200 µl Ask for price

GCK (untagged)-Human glucokinase (hexokinase 4, maturity onset diabetes of the young 2), transcript variant 1 (cDNA clone MGC:1742 IMAGE:3536582)

SC127236 10 µg Ask for price

Diabeton

413648 5.0g
EUR 234

Lung Diabetic Disease Lysate

XBL-10362 0.1 mg
EUR 796.2
Description: Human lung tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human lung tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the lung tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The lung tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Colon Diabetic Disease Lysate

XBL-10333 0.1 mg
EUR 796.2
Description: Human colon tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human colon tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the colon tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The colon tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Ileum Diabetic Disease Lysate

XBL-10379 0.1 mg
EUR 796.2
Description: Human small intestine: Ileum tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human small intestine: Ileum tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the small intestine: Ileum tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The small intestine: Ileum tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Total RNA - Diabetic Disease: Colon

R1236090Dia-50 50 ug
EUR 421.2

Jejunum Diabetic Disease Lysate

XBL-10381 0.1 mg
EUR 796.2
Description: Human small intestine: Jejunum tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human small intestine: Jejunum tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the small intestine: Jejunum tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The small intestine: Jejunum tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Stomach Diabetic Disease Lysate

XBL-10387 0.1 mg
EUR 796.2
Description: Human stomach tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human stomach tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the stomach tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The stomach tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Total RNA - Diabetic Disease: Stomach

R1236248Dia-50 50 ug
EUR 421.2

Duodenum Diabetic Disease Lysate

XBL-10336 0.1 mg
EUR 796.2
Description: Human duodenum tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human duodenum tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the duodenum tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The duodenum tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Total RNA - Diabetic Disease: Pancreas

R1236188Dia-50 50 ug
EUR 421.2

Esophagus Diabetic Disease Lysate

XBL-10338 0.1 mg
EUR 796.2
Description: Human esophagus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human esophagus tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the esophagus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The esophagus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Pancrease Diabetic Disease Lysate

XBL-10371 0.1 mg
EUR 796.2
Description: Human pancrease tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human pancrease tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the pancrease tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The pancrease tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Total RNA - Diabetic Disease: Esophagus

R1236106Dia-50 50 ug
EUR 421.2

cDNA - Human Diabetic Diseased Tissue: Lung

C1236152Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Skin

C1236218Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Brain

C1236035Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Colon

C1236090Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Heart

C1236122Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Liver

C1236149Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Whole Eye

C1236108Dia-10 10 reactions
EUR 393

cDNA - Human Diabetic Diseased Tissue: Kidney

C1236142Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Spleen

C1236246Dia 40 reactions
EUR 729

Skeletal Muscle Diabetic Disease Lysate

XBL-10369 0.1 mg
EUR 796.2
Description: human skeletal muscle tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human skeletal muscle tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the Skeletal Muscle tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The Skeletal Muscle tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

cDNA - Human Diabetic Diseased Tissue: Lymph Node

C1236161Dia-10 10 reactions
EUR 393

cDNA - Human Diabetic Diseased Tissue: Stomach

C1236248Dia 40 reactions
EUR 729

Human Keratinocytes, Adult, Diabetic Donor

ABC-TC3031 1 vial Ask for price
Description: Gentaur epidermal keratinocytes are available from adult and neonatal donor tissue and are provided at the earliest passage without the use of a murine feeder layer. Keratinocytes are available from donors of varying ages, genders, and diabetes status. Donor matched epidermal keratinocytes, dermal fibroblasts, melanocytes and subcutaneous preadipocytes are available.

cDNA - Human Diabetic Diseased Tissue: Bone Marrow

C1236024Dia-10 10 reactions
EUR 420

cDNA - Human Diabetic Diseased Tissue: Pancreas

C1236188Dia 40 reactions
EUR 729

Pancreas Membrane Diabetic Disease Lysate

XBL-10785 0.1 mg
EUR 752.1
Description: Human pancreas tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human pancreas tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated pancreas tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated pancreas tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Human Mesothelial Cells, Adult, Diabetic Donor

ABC-TC3484 1 vial Ask for price
Description: Mesothelial cells play pivotal roles in ovarian cancer metastasis, peritoneal dialysis, surgical adhesions, inflammatory response, and metabolic disease. These specialized epithelial cells form a single cell layer with a critical barrier function and provide a frictionless surface for organs and tissue to move without damage. We isolate peritoneal mesothelial cells from omental tissue biopsies with minimal propagation.

cDNA - Human Diabetic Diseased Tissue: Esophagus

C1236106Dia 40 reactions
EUR 729

Membrane Protein - Diabetic Disease: Pancreas

P3236188Dia 0.1 mg
EUR 410

Total Protein - Human Diabetic Diseased Tissue: Lung

P1236152Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Skin

P1236218Dia 1 mg
EUR 471

OCPB00557-100UG - Lung Diabetic Disease Lysate

OCPB00557-100UG 0.1mg
EUR 739

HighQC™ Diabetic Type I And Type II Adipose Derived Stem Cell

ABC-SC2109 1 vial Ask for price
Description: Human Adipose Derived Stem Cells (ADSC) from normal (non-diabetic) donors are available as a separate product. These cells have demonstrated very similar phenotypic and functional characteristics to that of bone marrow-derived mesenchymal stem cells. Diabetic Human Adipose Derived Stem Cells (ADSC) have been reported to differentiate down many different lineages including chondrogenic, osteogenic, adipogenic and neural. Diabetic Human Adipose Derived Stem Cells (ADSC) have been cryopreserved at primary passage.

Adipose Subcutaneous Diabetic Disease Lysate

20-105 0.1 mg
EUR 1508.1
Description: Human subcutaneous adipose tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human subcutaneous adipose tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the subcutaneous adipose tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The subcutaneous adipose tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Total Protein - Human Diabetic Diseased Tissue: Brain

P1236035Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Colon

P1236090Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Heart

P1236122Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Liver

P1236149Dia 1 mg
EUR 471

OCPB00528-100UG - Colon Diabetic Disease Lysate

OCPB00528-100UG 0.1mg
EUR 739

OCPB00573-100UG - Ileum Diabetic Disease Lysate

OCPB00573-100UG 0.1mg
EUR 739

cDNA - Human Diabetic Diseased Tissue: Skeletal Muscle

C1236171Dia 40 reactions
EUR 729

Total Protein - Human Diabetic Diseased Tissue: Whole Eye

P1236108Dia 1 mg
EUR 1147

Total Protein - Human Diabetic Diseased Tissue: Kidney

P1236142Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Spleen

P1236246Dia 1 mg
EUR 471

Skeletal Muscle Membrane Diabetic Disease Lysate

XBL-10855 0.1 mg
EUR 752.1
Description: human skeletal muscle tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human skeletal muscle tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated Skeletal Muscle tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated Skeletal Muscle tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

cDNA - Human Diabetic Diseased Tissue: Visceral Adipose

C1236003VisDia-10 10 reactions
EUR 420

Membrane Protein - Diabetic Disease: Skeletal Muscle

P3236171Dia 0.1 mg
EUR 410

Total Protein - Human Diabetic Diseased Tissue: Adrenal

P1236004Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Stomach

P1236248Dia 1 mg
EUR 471

OCPB00575-100UG - Jejunum Diabetic Disease Lysate

OCPB00575-100UG 0.1mg
EUR 739

OCPB00579-100UG - Stomach Diabetic Disease Lysate

OCPB00579-100UG 0.1mg
EUR 739

Total Protein - Human Diabetic Diseased Tissue: Bone Marrow

P1236024Dia 1 mg
EUR 1147

Total Protein - Human Diabetic Diseased Tissue: Pancreas

P1236188Dia 1 mg
EUR 471

OCPB00531-100UG - Duodenum Diabetic Disease Lysate

OCPB00531-100UG 0.1mg
EUR 739

Human Dermal Microvascular EndoCells Diabetic Type I

ABC-TC3401 1 vial Ask for price
Description: Diseased endothelial cells are isolated from human donors that have been diagnosed with diabetes type I or type II disease. Diseased cells are grown in the same optimized media system as normal human dermal microvascular endothelial cells.

Human Dermal Microvascular EndoCells Diabetic Type II

ABC-TC3402 1 vial Ask for price
Description: Diseased endothelial cells are isolated from human donors that have been diagnosed with diabetes type I or type II disease. Diseased cells are grown in the same optimized media system as normal human dermal microvascular endothelial cells.

Frozen Tissue Section - Human Diabetic Diseased Tissue: Eye

T1236108Dia 5 slides
EUR 662

cDNA - Human Diabetic Diseased Tissue: Small Intestine: Ileum

C1236227Dia 40 reactions
EUR 729

Total Protein - Human Diabetic Diseased Tissue: Esophagus

P1236106Dia 1 mg
EUR 471

OCPB00533-100UG - Esophagus Diabetic Disease Lysate

OCPB00533-100UG 0.1mg
EUR 739

OCPB00566-100UG - Pancrease Diabetic Disease Lysate

OCPB00566-100UG 0.1mg
EUR 739

Frozen Tissue Section - Human Diabetic Diseased Tissue: Lung

T1236152Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Skin

T1236218Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Brain

T1236035Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Colon

T1236090Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Heart

T1236122Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Liver

T1236149Dia 5 slides
EUR 475

cDNA - Human Diabetic Diseased Tissue: Subcutaneous Adipose

C1236003SubDia-10 10 reactions
EUR 420

cDNA - Human Diabetic Diseased Tissue: Small Intestine: Jejunum

C1236230Dia 40 reactions
EUR 729

Genomic DNA - Human Diabetic Diseased Tissue: Lung, from a single donor

D1236152Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Skin, from a single donor

D1236218Dia 50 ug
EUR 489

Frozen Tissue Section - Human Diabetic Diseased Tissue: Kidney

T1236142Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Spleen

T1236246Dia 5 slides
EUR 475

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Lung

T2236152Dia 5 slides
EUR 238

cDNA - Human Diabetic Diseased Tissue: Small Intestine: Duodenum

C1236101Dia 40 reactions
EUR 729

Genomic DNA - Human Diabetic Diseased Tissue: Colon, from a single donor

D1236090Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Heart, from a single donor

D1236122Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Liver, from a single donor

D1236149Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Brain, from a single donor

D1236035Dia 50 ug
EUR 489

Total Protein - Human Diabetic Diseased Tissue: Skeletal Muscle

P1236171Dia 1 mg
EUR 471

OCPB00564-100UG - Skeletal Muscle Diabetic Disease Lysate

OCPB00564-100UG 0.1mg
EUR 739

Diabetic Mouse Cardiac Microvascular Endothelial Cells

ABC-HP022X 1 vial Ask for price
Description: Diabetic Mouse Cardiac Microvascular Endothelial Cells are isolated from the heart of Diabetic (db/db) mice. Diabetic Mouse Cardiac Microvascular Endothelial Cells are cryopreserved at passage 3 and delivered frozen.

Frozen Tissue Section - Human Diabetic Diseased Tissue: Adrenal

T1236004Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Stomach

T1236248Dia 5 slides
EUR 475

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Colon

T2236090Dia 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Liver

T2236149Dia 5 slides
EUR 238

Genomic DNA - Human Diabetic Diseased Tissue: Whole Eye, from a single donor

D1236108Dia 50 ug
EUR 1152

Bij bivariate evaluatie werd gebruikgemaakt van een chi-kwadraattest met een significantiestadium van p <0,05 en een betrouwbaarheidsinterval (BI) van 95%, en een multivariate evaluatie met behulp van een aantal logistische regressiecontroles.

Factoren die diabetes mellitus beïnvloeden, waren leeftijd> 55 jaar (OR = 5,10; 95% BI 4,42 tot 5,89; p <0,001), vrouwelijk (OR = 1,37; 95% BI 1,26 tot 1,49; p <0,001), landelijk (OR = 1,16; 95% BI 1,08 tot 1,26; p <0,001), getrouwd (OR = 1,31; 95% BI 1,07 tot 1,58; p <0,05), werkloos (OR = 1,14; 96% BI 1,05 tot 1,23; p <0,05) gewichtsproblemen (OR = 1,46; 95% BI 1,35 tot 1,58; p <0,001), hypertensie (OR = 1,68; 95% BI 1,55 tot 1,81; p <0,001) en dyslipidemie (OR = 1,53; 95% BI 1,39-1,68 ; P <0,001). CONCLUSIES Maar liefst 13% van de mensen heeft diabetes mellitus in 2013. Leeftijd, geslacht, woonruimte, werkgelegenheidsstatus, gewichtsproblemen, hypertensie en dyslipidemie zijn de bijdragende componenten aan diabetes mellitus.

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