Op bloed gebaseerde FTIR-ATR-spectroscopie in combinatie met extreme gradiëntversterking voor de diagnose van type 2-diabetes: een STARD-compatibel diagnoseonderzoek.

Tijdige analyse van diabetes type 2 en vroege interventie en therapie ervan zijn van vitaal belang voor het beheersen van metabole problemen, het vertragen en verminderen van problemen, het verminderen van sterfte en het verbeteren van een hoge kwaliteit van leven. Type 2 diabetes werd herkend door Fourier rework mid-infrarood (FTIR) verzwakte volledige reflectie (ATR) spectroscopie samen met overmatige gradiëntversterking (XGBoost).

Volbloed FTIR-ATR-spectra van 51 klinisch erkende diabetes type 2 en 55 gezonde vrijwilligers waren verzameld. Voor de gecompliceerde samenstelling van volledig bloed en verre spectrale ruis werd Savitzky-Golay-afvlakking voor het eerst toegepast op het FTIR-ATR-spectrum.

Vervolgens werd PCA gebruikt om overbodige kennis uit te roeien en verwierf het een van de beste variëteit aan receptonderdelen. Ten slotte werd het XGBoost-algoritme gebruikt om de soort 2-diabetes te onderscheiden van gezonde vrijwilligers en het grid-zoekalgoritme werd gebruikt om de gerelateerde parameters van de XGBoost-mannequin te optimaliseren om de robuustheid en generalisatiemiddelen van de mannequin te verbeteren.

De gevoeligheid van de optimale XGBoost-paspop was 95,23% (20/21), de specificiteit was 96,00% (24/25) en de nauwkeurigheid was 95,65% (44/46). De experimentele resultaten tonen aan dat FTIR-ATR-spectroscopie vermengd met XGBoost-algoritme diabetes type 2 snel en nauwkeurig kan diagnosticeren zonder reagentia.

Vermindering van de sterftekosten bij ouderen met diabetes: een overzicht van huidig ​​onderzoek.

Bij deze beoordeling wordt gekeken naar de mortaliteitslast die wordt opgemerkt bij de oudere inwoners van mensen met diabetes en worden de kanscomponenten geïdentificeerd die verband houden met het sterfterisico bij deze inwoners.

Het sterfte-gat tussen oudere mensen met en zonder diabetes blijft bestaan, waarbij de extra sterfte 10% hoger is dan binnen de normale bewoners. Hoewel de vroege sterfte bij mannen met diabetes aanzienlijk hoger is dan bij vrouwen met diabetes, is het relatieve sterfterisico bij vrouwen veel groter in vergelijking met meisjes zonder diabetes.

Oudere personen die diabetes hebben ontwikkeld op middelbare leeftijd hebben een aanzienlijk groter risico op sterfte in vergelijking met degenen die het ontwikkelen op verouderde leeftijd, wat de blijvende betekenis benadrukt van het optimaliseren van diabeteszorg op alle leeftijden.

Novobiocin sodium
N014-1G	TOKU-E	1 g	EUR 78

Novobiocin sodium
N014-5G	TOKU-E	5 g	EUR 188.4

Novobiocin (Sodium)
HY-B0425A	MedChemExpress	10mM/1mL	EUR 223.2

Novobiocin Supplement
MED1556	Scientific Laboratory Supplies	PK10	EUR 57.12

Novobiocin Sodium Salt
B1526-1G	Biovision	each	EUR 130.8

Novobiocin Sodium Salt
B1526-5G	Biovision	each	EUR 288

Novobiocin sodium salt
GA5711-1G	Glentham Life Sciences	1 g	EUR 84

Novobiocin sodium salt
GA5711-5G	Glentham Life Sciences	5 g	EUR 199.2

TSB w Novobiocin-20mg/L
MED1130	Scientific Laboratory Supplies	PK50	EUR 54

Novo-TRX
27500	BPS Bioscience	20 µl	EUR 335
Description: Novobiocin is an aminocoumarin antibiotic that is produced by Streptomyces niveus. Along with other aminocoumarin antibiotics, novobiocin is a very potent inhibitor of bacterial DNA gyrase. It works by targeting the GyrB subunit of the enzyme involved in energy transduction. Novo-TRX is Texas Red-labeled novobiocin, which can be used as a fluorescence probe in assays for screening DNA gyrase inhibitors.

Novo? cDNA Kit
M1165-100	Biovision	each	EUR 424.8

Novo? cDNA Kit
M1165-25	Biovision	each	EUR 320.4

Novo? Two Step RT Kit
M1161-100	Biovision	each	EUR 457.2

Novo? Two Step RT Kit
M1161-25	Biovision	each	EUR 320.4

Novokinin
B5461-1	ApexBio	1 mg	EUR 350.4

Novo? cDNA Supermix
M1169-100	Biovision	each	EUR 529.2

Novo? cDNA Supermix
M1169-25	Biovision	each	EUR 346.8

Novo? Transcriptome cDNA Kit
M1167-100	Biovision	each	EUR 1142.4

Novo? Transcriptome cDNA Kit
M1167-25	Biovision	each	EUR 529.2

Novo? Reverse Transcriptase
M1174-100	Biovision	each	EUR 457.2

Novo? Reverse Transcriptase
M1174-25	Biovision	each	EUR 385.2

MK TETRATHIONATE NOVO COMPLETE
MED1114	Scientific Laboratory Supplies	PK50	EUR 58.8

Recombinant Human Fibronectin Fragment/RetroNectin/NovoNectin
CH38-10ug	Novoprotein	10ug	EUR 96
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human Fibronectin Fragment/RetroNectin/NovoNectin
CH38-1mg	Novoprotein	1mg	EUR 522
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human Fibronectin Fragment/RetroNectin/NovoNectin
CH38-500ug	Novoprotein	500ug	EUR 375.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human Fibronectin Fragment/RetroNectin/NovoNectin
CH38-50ug	Novoprotein	50ug	EUR 157.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Nov/ Rat Nov ELISA Kit
ELI-35315r	Lifescience Market	96 Tests	EUR 1063.2

Nova1/ Rat Nova1 ELISA Kit
ELI-44616r	Lifescience Market	96 Tests	EUR 1063.2

LKB Pharmacia Ultrospec 2000 3000 Novaspec ii Tungsten Lamp
LT-LKB-100	Scientific Laboratory Supplies	EACH	EUR 49.2

Chicken Protein NOV, NOV ELISA KIT
ELI-38132c	Lifescience Market	96 Tests	EUR 1113.6

Rat Protein NOV homolog(NOV) ELISA kit
CSB-EL015956RA-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Protein NOV homolog (NOV) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Protein NOV homolog(NOV) ELISA kit
1-CSB-EL015956RA	Cusabio	EUR 843.60 EUR 5811.60 EUR 3084.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Protein NOV homolog(NOV) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Protein NOV Homolog (NOV) Antibody
20-abx214413	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Protein NOV Homolog (NOV) Antibody
20-abx325508	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Protein NOV Homolog (NOV) Antibody
20-abx320575	Abbexa	EUR 360.00 EUR 292.80	100 ul 50 ul

Protein NOV Homolog (NOV) Antibody
20-abx006766	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Human Protein NOV homolog(NOV) ELISA kit
CSB-EL015956HU-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitative sandwich ELISA kit for measuring Human Protein NOV homolog (NOV) in samples from serum, plasma, tissue homogenates . A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Protein NOV homolog(NOV) ELISA kit
1-CSB-EL015956HU	Cusabio	EUR 843.60 EUR 5811.60 EUR 3084.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Protein NOV homolog(NOV) in samples from serum, plasma, tissue homogenates . Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Protein NOV homolog(NOV) ELISA kit
CSB-EL015956MO-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Protein NOV homolog (NOV) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Protein NOV homolog(NOV) ELISA kit
1-CSB-EL015956MO	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Protein NOV homolog(NOV) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Protein NOV homolog, NOV ELISA KIT
ELI-35314h	Lifescience Market	96 Tests	EUR 988.8

Mouse Protein NOV homolog, Nov ELISA KIT
ELI-14991m	Lifescience Market	96 Tests	EUR 1038

NOVATest Antigen Rapid Kit (NOVA Test)
nCov-500	Atlas Link Technology	20 Tests	EUR 162

Mouse Protein NOV Homolog (NOV) Protein
20-abx261807	Abbexa	EUR 5238.00 EUR 393.60 EUR 276.00	1 mg 20 ug 5 ug

Human Protein NOV Homolog (NOV) Protein
20-abx261834	Abbexa	EUR 5254.80 EUR 393.60 EUR 276.00	1 mg 20 ug 5 ug

Human RNA- binding protein Nova- 2, NOVA2 ELISA KIT
ELI-36919h	Lifescience Market	96 Tests	EUR 988.8

Human RNA- binding protein Nova- 1, NOVA1 ELISA KIT
ELI-21240h	Lifescience Market	96 Tests	EUR 988.8

Mouse RNA- binding protein Nova- 1, Nova1 ELISA KIT
ELI-22111m	Lifescience Market	96 Tests	EUR 1038

NOVATest IgG/IgM Antibody Rapid Test Kit (NOVA Test)
UNCOV-40	Atlas Link Technology	40 Tests	EUR 115

ELISA kit for Human RNA-binding protein Nova-2 (NOVA2)
KTE62364-48T	Abbkine	48T	EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human RNA-binding protein Nova-2 (NOVA2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human RNA-binding protein Nova-2 (NOVA2)
KTE62364-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2538
Description: Quantitative sandwich ELISA for measuring Human RNA-binding protein Nova-2 (NOVA2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human RNA-binding protein Nova-2 (NOVA2)
KTE62364-96T	Abbkine	96T	EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human RNA-binding protein Nova-2 (NOVA2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

NOVATest Antigen Rapid Test Kit (For Single Use) (NOVA Test)
nCov-500-01	Atlas Link Technology	1T	EUR 162

NOV siRNA
20-abx926185	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

NOV siRNA
20-abx926186	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

NOV siRNA
20-abx903608	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

NOVA Alternative Splicing Regulator 2 (NOVA2) Antibody
abx235802-100ug	Abbexa	100 ug	EUR 610.8

NOVA Alternative Splicing Regulator 2 (NOVA2) Antibody
abx029973-400ul	Abbexa	400 ul	EUR 627.6

NOVA Alternative Splicing Regulator 2 (NOVA2) Antibody
abx029973-80l	Abbexa	80 µl	EUR 343.2

Human NOVA Alternative Splicing Regulator 2 (NOVA2) ELISA Kit
abx381853-96tests	Abbexa	96 tests	EUR 1093.2

NOV Rabbit pAb
A5320-100ul	Abclonal	100 ul	EUR 369.6

NOV Rabbit pAb
A5320-200ul	Abclonal	200 ul	EUR 550.8

NOV Rabbit pAb
A5320-20ul	Abclonal	20 ul	EUR 219.6

NOV Rabbit pAb
A5320-50ul	Abclonal	50 ul	EUR 267.6

NOV Rabbit pAb
A14488-100ul	Abclonal	100 ul	EUR 369.6

NOV Rabbit pAb
A14488-200ul	Abclonal	200 ul	EUR 550.8

NOV Rabbit pAb
A14488-20ul	Abclonal	20 ul	EUR 219.6

NOV Rabbit pAb
A14488-50ul	Abclonal	50 ul	EUR 267.6

NOV protein
30R-AN038	Fitzgerald	20 ug	EUR 327.6
Description: Purified recombinant Human NOV protein

NOVA1 siRNA
20-abx926182	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

NOVA1 siRNA
20-abx926183	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

NOVA2 siRNA
20-abx926184	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

NOV antibody
70R-1714	Fitzgerald	100 ug	EUR 452.4
Description: Rabbit polyclonal NOV antibody raised against the middle region of NOV

NOV antibody
70R-1715	Fitzgerald	100 ug	EUR 452.4
Description: Rabbit polyclonal NOV antibody raised against the C terminal of NOV

NOV antibody
70R-NR012	Fitzgerald	50 ug	EUR 327.6
Description: Affinity purified Rabbit polyclonal NOV antibody

NOV Antibody
36547-100ul	SAB	100ul	EUR 302.4

NOV Antibody
1-CSB-PA005674	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against NOV. Recognizes NOV from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

NOV Antibody
1-CSB-PA015956ESR2HU	Cusabio	EUR 266.40 EUR 402.00	100ul 50ul
Description: A polyclonal antibody against NOV. Recognizes NOV from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

NOV Antibody
1-CSB-PA987170	Cusabio	EUR 380.40 EUR 292.80	100ul 50ul
Description: A polyclonal antibody against NOV. Recognizes NOV from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:500-1:2000, IHC:1:25-1:100

Novaluron
HY-17519	MedChemExpress	100mg	EUR 325.2

NOVA1 Peptide
46-694P	ProSci	0.1 mg	EUR 405.6
Description: NOVA1 Peptide

NOVA1 Rabbit pAb
A12030-100ul	Abclonal	100 ul	EUR 369.6

NOVA1 Rabbit pAb
A12030-200ul	Abclonal	200 ul	EUR 550.8

NOVA1 Rabbit pAb
A12030-20ul	Abclonal	20 ul	EUR 219.6

NOVA1 Rabbit pAb
A12030-50ul	Abclonal	50 ul	EUR 267.6

NOV ELISA KIT|Human
EF001289	Lifescience Market	96 Tests	EUR 826.8

Gloria Nova HS PCR Kit
RK20714	Abclonal	20 RXNS	Ask for price

NOVA2 antibody
70R-1370	Fitzgerald	100 ug	EUR 452.4
Description: Rabbit polyclonal NOVA2 antibody raised against the middle region of NOVA2

NOVA1 antibody
70R-12687	Fitzgerald	100 ul	EUR 548.4
Description: Affinity purified Rabbit polyclonal NOVA1 antibody

NOVA2 antibody
70R-18929	Fitzgerald	50 ul	EUR 522
Description: Rabbit polyclonal NOVA2 antibody

NOVA2 antibody
70R-1469	Fitzgerald	100 ug	EUR 452.4
Description: Rabbit polyclonal NOVA2 antibody raised against the N terminal of NOVA2

NOVA1 antibody
22767-100ul	SAB	100ul	EUR 468

NOVA1 antibody
70R-4832	Fitzgerald	50 ug	EUR 560.4
Description: Rabbit polyclonal NOVA1 antibody raised against the C terminal of NOVA1

NOVA1 antibody
70R-5002	Fitzgerald	50 ug	EUR 560.4
Description: Rabbit polyclonal NOVA1 antibody raised against the middle region of NOVA1

NOVA1 Antibody
1-CSB-PA015957LA01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against NOVA1. Recognizes NOVA1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

NOVA2 Antibody
1-CSB-PA015958GA01HU	Cusabio	EUR 716.40 EUR 399.60	150ul 50ul
Description: A polyclonal antibody against NOVA2. Recognizes NOVA2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

Nova1 Antibody
DF14153	Affbiotech	100ul	EUR 420

NOVA2 Antibody
DF15644	Affbiotech	100ul	EUR 420

Novel Green PLUS (20000X)
LD003-0500	GeneOn	500 µl	EUR 206.4

Novel Green PLUS (20000X)
LD003-0500L	GeneOn	5x500 µl	EUR 877.2

anti- NOV antibody
FNab05801	FN Test	100µg	EUR 606.3
Description: Antibody raised against NOV

Nov ORF Vector (Rat) (pORF)
ORF071423	ABM	1.0 ug DNA	EUR 607.2

NOVA1 Antibody
RQ4592	NSJ Bioreagents	100ug	EUR 356.15
Description: RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene. It is mapped to 14q12. This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.

NOVA2 Antibody
RQ5998	NSJ Bioreagents	100 ug	EUR 356.15
Description: NOVA alternative splicing regulator 2 is a protein that in humans is encoded by the NOVA2 gene. It is mapped to 19q13.32. NOVA2 may regulate RNA splicing or metabolism in a specific subset of developing neurons. It binds single strand RNA.

NOVA1 Antibody
R35595-100UG	NSJ Bioreagents	100 ug	EUR 339.15
Description: Additional name(s) for this target protein: Neuro-oncological ventral antigen 1

NOVATest VAPERON Neutralizing Antibody Rapid Detection Kit (NOVA Test)
COVNA-503	Atlas Link Technology	20 Tests	Ask for price

Rat NOV shRNA Plasmid
20-abx986601	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Human NOV/CCN3 ELISA Kit
LF-EK50926	Abfrontier	1×96T	EUR 777.6

NOVA2 ELISA KIT|Human
EF001290	Lifescience Market	96 Tests	EUR 826.8

NOV cloning plasmid
CSB-CL015956HU-10ug	Cusabio	10ug	EUR 493.2
Description: A cloning plasmid for the NOV gene.

NOV ORF Vector (Human) (pORF)
ORF007166	ABM	1.0 ug DNA	EUR 114

ELISA kit for Human NOV/CCN3
EK5373	SAB	96 tests	EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human NOV/CCN3 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Mouse NOV/CCN3
EK5374	SAB	96 tests	EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse NOV/CCN3 in samples from serum, plasma, tissue homogenates and other biological fluids.

anti- NOVA2 antibody
FNab05802	FN Test	100µg	EUR 658.5
Description: Antibody raised against NOVA2

Nov ORF Vector (Mouse) (pORF)
ORF051542	ABM	1.0 ug DNA	EUR 607.2

Gloria Nova HS 2x Master Mix
RK20717	Abclonal	1mL	Ask for price

NOV 3'UTR GFP Stable Cell Line
TU065842	ABM	1.0 ml	EUR 1672.8

Nov 3'UTR GFP Stable Cell Line
TU264097	ABM	1.0 ml	Ask for price

Nov 3'UTR GFP Stable Cell Line
TU164225	ABM	1.0 ml	Ask for price

Mouse NOV shRNA Plasmid
20-abx971787	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

NOV Blocking Peptide
33R-8084	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NOV antibody, catalog no. 70R-1714

NOV Blocking Peptide
33R-4680	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NOV antibody, catalog no. 70R-1715

Human NOV shRNA Plasmid
20-abx953228	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Nori® Human NOV/CCN3 ELISA Kit
GR106385	Genorise Scientific	96-well	EUR 461

NOV ELISA Kit (Rat) (OKCA00996)
OKCA00996	Aviva Systems Biology	96 Wells	EUR 999.6
Description: Description of target: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival. Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts. Involved in bone regeneration as a negative regulator. Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification . Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion. Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway. Contributes to the control and coordination of inflammatory processes in atherosclerosis. Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement .;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 7.81 ng/mL

NOVA1 ORF Vector (Human) (pORF)
ORF026185	ABM	1.0 ug DNA	EUR 114

NOVA2 ORF Vector (Human) (pORF)
ORF026187	ABM	1.0 ug DNA	Ask for price

Nova1 ORF Vector (Mouse) (pORF)
ORF051543	ABM	1.0 ug DNA	EUR 607.2

Nova2 ORF Vector (Mouse) (pORF)
ORF051544	ABM	1.0 ug DNA	EUR 607.2

NOVA1 3'UTR GFP Stable Cell Line
TU065843	ABM	1.0 ml	EUR 1825.2

NOVA2 3'UTR GFP Stable Cell Line
TU065844	ABM	1.0 ml	EUR 1672.8

Nova1 3'UTR GFP Stable Cell Line
TU264098	ABM	1.0 ml	Ask for price

Nova2 3'UTR GFP Stable Cell Line
TU264099	ABM	1.0 ml	Ask for price

Nova1 3'UTR GFP Stable Cell Line
TU164226	ABM	1.0 ml	Ask for price

Nova2 3'UTR GFP Stable Cell Line
TU164227	ABM	1.0 ml	Ask for price

Mouse NOVA1 shRNA Plasmid
20-abx984227	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Nova Microcinerator
ARG1776	Scientific Laboratory Supplies	EACH	EUR 306.66

NOVA1 Blocking Peptide
33R-9210	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NOVA1 antibody, catalog no. 70R-5002

NOVA2 Blocking Peptide
33R-2631	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NOVA2 antibody, catalog no. 70R-1370

NOVA2 Blocking Peptide
33R-5942	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NOVA2 antibody, catalog no. 70R-1469

NOVA1 Blocking Peptide
33R-8555	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NOVA1 antibody, catalog no. 70R-4832

Norovirus (NOV) Antibody
abx023841-1mg	Abbexa	1 mg	EUR 1011.6

Norovirus (NOV) Antibody
abx023842-1mg	Abbexa	1 mg	EUR 1011.6

Norovirus (NOV) Antibody
abx023843-1mg	Abbexa	1 mg	EUR 1011.6

Norovirus (NOV) Antibody
abx023844-1mg	Abbexa	1 mg	EUR 1011.6

Norovirus (NOV) Antibody
abx023845-1mg	Abbexa	1 mg	EUR 1011.6

Norovirus (NOV) Antibody
abx023846-1mg	Abbexa	1 mg	EUR 1011.6

Norovirus (NOV) Antibody
abx023847-1mg	Abbexa	1 mg	EUR 1011.6

Norovirus (NOV) Antibody
abx022119-1mg	Abbexa	1 mg	EUR 1128

Norovirus (NOV) Antibody
abx022120-1mg	Abbexa	1 mg	EUR 1128

Human NOVA1 shRNA Plasmid
20-abx953229	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Human NOVA2 shRNA Plasmid
20-abx953230	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

NOV Recombinant Protein
92-639	ProSci	0.05 mg	EUR 481.2
Description: NOV, also called CCN3, is a secreted protein of CCN family members. CCN family members are highly conserved cysteine rich proteins sharing a common modular structure having 4 conserved domains, insulin-like growth factor-binding protein (IGFBP) domain, von Willebrand type C (VWC) domain, thrombospondin-1 (TSP-1) domain, and C-terminal (CT) domain (absent in CCN5). By specific interactions with these domains, CCN proteins modulate multiple signalling pathways including BMPs, Wnt, TGFs, Notch and integrins to regulate cell proliferation, differentiation, adhesion, migration, angiogenesis, and survival. CCN3 is firstly characterized as a promoter of progenitor activity of human hematopoietic stem cells, as knockdown of CCN3 can abrogate the function of primitive progenitors. Recent studies showed that CCN3 is also actively involved in the process of wound healing. CCN3 is highly expressed in granulation tissues of cutaneous wounds and capable of inducing synthetic responses of fibroblasts.

El Paper Novablot 200x250Mm P 500
80110619	Scientific Laboratory Supplies	EACH	EUR 488.4

Nov Polyclonal Antibody
ABP53143-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Nov from Human, Mouse. This Nov antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Nov

Nov Polyclonal Antibody
ABP53143-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Nov from Human, Mouse. This Nov antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Nov

Nov Polyclonal Antibody
ABP53143-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Nov from Human, Mouse. This Nov antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Nov

BRAND(TM) DESSICATOR NOVUS LID W
BR65738-1EA	Scientific Laboratory Supplies	EACH	EUR 153.6

NOV Recombinant Protein
40-222-0005mg	ProSci	0.005 mg	EUR 311.1
Description: NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm’s tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities. Recombinant human NOV is a 36.2 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).

NOV Recombinant Protein
40-222-002mg	ProSci	0.02 mg	EUR 437.1
Description: NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm’s tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities. Recombinant human NOV is a 36.2 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).

Nov Polyclonal Antibody
41797-100ul	SAB	100ul	EUR 302.4

Nov Polyclonal Antibody
41797-50ul	SAB	50ul	EUR 224.4

Mouse Norovirus (NoV) ELISA Kit
abx055035-96tests	Abbexa	96 tests	EUR 801.6

Human Norovirus (NoV) ELISA Kit
abx055762-96tests	Abbexa	96 tests	EUR 801.6

NOV Conjugated Antibody
C36547	SAB	100ul	EUR 476.4

NOV ELISA Kit (Mouse) (OKCA01755)
OKCA01755	Aviva Systems Biology	96 Wells	EUR 1015.2
Description: Description of target: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival. Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts. Involved in bone regeneration as a negative regulator (PubMed:23653360). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification. Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (PubMed:23705021). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway. Contributes to the control and coordination of inflammatory processes in atherosclerosis (PubMed:24722330). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sanadwich ELISA;Sensitivity: 5.85 pg/mL

Nov Polyclonal Antibody
ES4142-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Nov from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Nov Polyclonal Antibody
ES4142-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Nov from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

NOV ELISA Kit (Human) (OKBB00827)
OKBB00827	Aviva Systems Biology	96 Wells	EUR 606
Description: Description of target: NOV(nephroblastoma overexpressed), also known as CCN3, is a matricellular protein that in humans is encoded by the NOV gene. The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. This gene is mapped to 8q24.12. NOV is a potentially useful marker for the diagnosis of adrenal gland diseases, malignant adrenocortical tumors, multiple sclerosis and so on. Moreover, reduced expression of NOV in ACTs may play an important role in the process of childhood ACT tumorigenesis. Though studying, it identified Nov as a regulator of human hematopoietic stem or progenitor cells.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <2pg/ml

NOV ELISA Kit (Mouse) (OKBB00828)
OKBB00828	Aviva Systems Biology	96 Wells	EUR 606
Description: Description of target: NOV (nephroblastoma overexpressed), also known as CCN3, is a matricellular protein that in humans is encoded by the NOV gene. The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. This gene is mapped to 8q24.12. NOV is a potentially useful marker for the diagnosis of adrenal gland diseases, malignant adrenocortical tumors, multiple sclerosis and so on. Moreover, reduced expression of NOV in ACTs may play an important role in the process of childhood ACT tumorigenesis. Though studying, it identified Nov as a regulator of human hematopoietic stem or progenitor cells.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

Nov Protein Vector (Rat) (pPM-C-HA)
PV285692	ABM	500 ng	EUR 723.6

Nori® Human NOV/CCN3 ELISA Kit (2 plates)
GR106385-2	Genorise Scientific	2 x 96-well	EUR 832

Human NOV/CCN3 PicoKine ELISA Kit
EK0833	BosterBio	96 wells	EUR 510
Description: For quantitative detection of human NOV in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Mouse NOV/CCN3 PicoKine ELISA Kit
EK0834	BosterBio	96 wells	EUR 510
Description: For quantitative detection of mouse NOV in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

NOVA1-AS1 ORF Vector (Human) (pORF)
ORF026186	ABM	1.0 ug DNA	Ask for price

Nov Protein Vector (Rat) (pPB-C-His)
PV285690	ABM	500 ng	EUR 723.6

Nov Protein Vector (Rat) (pPB-N-His)
PV285691	ABM	500 ng	EUR 723.6

Nov Protein Vector (Rat) (pPM-C-His)
PV285693	ABM	500 ng	EUR 723.6

Recombinant NoV VP1 Protein
VAng-Wyb3670-50g	Creative Biolabs	50 µg	EUR 1693.2
Description: Norovirus VP1, recombinant protein.

NOVA1 Polyclonal Antibody
27594-100ul	SAB	100ul	EUR 302.4

NOVA1 Polyclonal Antibody
27594-50ul	SAB	50ul	EUR 224.4

Nov Protein Vector (Human) (pPM-C-HA)
PV028663	ABM	500 ng	EUR 394.8

Nov Protein Vector (Mouse) (pPM-C-HA)
PV206168	ABM	500 ng	EUR 723.6

Recombinant NoV VP2 Protein (aa 21-275) [His]
VAng-Wyb3653-100g	Creative Biolabs	100 µg	EUR 4002
Description: Norovirus (strain swine/GII/OH-QW125/03/US) VP2 protein, recombinant protein.

Recombinant NoV VP2 Protein (aa 21-275) [His]
VAng-Wyb3653-500g	Creative Biolabs	500 µg	EUR 9794.4
Description: Norovirus (strain swine/GII/OH-QW125/03/US) VP2 protein, recombinant protein.

Nova Microcinerator Loop Rest
ARG1774	Scientific Laboratory Supplies	EACH	EUR 39.82

NOVA1 Antibody, HRP conjugated
1-CSB-PA015957LB01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against NOVA1. Recognizes NOVA1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

NOV ELISA Kit (Human) : 96 Wells (OKAG00054)
OKAG00054	Aviva Systems Biology	96 Wells	EUR 715.2
Description: Description of target: The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 63 pg/mL

Recombinant Human NOV Protein
PROTP48745-2	BosterBio	20ug	EUR 380.4
Description: NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm’s tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities. Recombinant human NOV is a 36.2 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).

Om het sterfterisico op oudere leeftijd te verminderen, is het een zeer belangrijke aanpak van de componenten die gevaar opleveren, namelijk: comorbiditeit; polyfarmacie; lichamelijke en psychologische kwetsbaarheid; beschermde glycemische doelen voor oudere mensen ; hypoglykemie; glycemische doelen; en de hypoglycemische makelaars.

Hoewel de informatie om optimale toedieningsbenaderingen te vinden beperkt is, is de algemene behoefte aan een extra ijverige methode om de behoeften van oudere mensen met diabetes te beoordelen om geïndividualiseerde zorgmethoden te vertellen en doelen te verhelpen die potentiële gevaren verminderen.