Diabetes en COVID-19: bewijs, huidige status en onbeantwoorde onderzoeksvragen.

Patiënten met diabetes die coronavirusziekte 2019 (COVID-19) krijgen, lopen een extreem ziekteverloop en sterfte. Verschillende elementen, met name de verminderde immuunrespons, verhoogde ontstekingsreactie en hypercoaguleerbare toestand, dragen bij tot de verhoogde ernst van de ziekte. Er zijn echter veel controversiële punten waarover het bewijs enigszins beperkt is.

Er zijn enkele theoretische overwegingen met betrekking tot de resultaten van verschillende anti-hyperglykemische medicatie. Evenzo, ongeacht de populariteit van angiotensine-veranderend enzym 2 (ACE2) omdat de receptor voor extreem acuut respiratoir syndroom coronavirus 2 (SARS CoV-2) en de functie van ACE2 bij longschade; er zijn tegenstrijdige resultaten bij het gebruik van angiotensine-veranderende enzym (ACE) -remmers en angiotensine-receptorblokkers (ARB) bij deze patiënten.

Het beheer van diabetespatiënten in geval van mobiliteitsbeperkingen stelt enkele uitdagingen en nieuwe benaderingen zoals telegeneeskunde kunnen nuttig zijn. Het zuivere beloop van COVID-19 bij diabetespatiënten moet verder worden onderzocht en de persoon moet worden begrepen, regionale en etnische verschillen in ziekteprevalentie en beloop.

Diabetes en COVID-19: bewijs, huidige status en onbeantwoorde onderzoeksvragen.

Patiënten met diabetes die coronavirusziekte 2019 (COVID-19) krijgen, lopen een extreem ziekteverloop en sterfte. Verschillende elementen, met name de verminderde immuunrespons, verhoogde ontstekingsreactie en hypercoaguleerbare toestand, dragen bij tot de verhoogde ernst van de ziekte.

Er zijn echter veel controversiële punten waarover het bewijs enigszins beperkt is. Er zijn enkele theoretische overwegingen met betrekking tot de resultaten van verschillende anti-hyperglykemische medicatie.

NP-40 Lysis Buffer 2X
22040064-1	Bio-WORLD	125 mL	EUR 36.51

NP-40 Lysis Buffer 2X
22040064-2	Bio-WORLD	250 mL	EUR 61.95

NP-40 Lysis Buffer 2X
22040064-3	Bio-WORLD	500 mL	EUR 94.44

NP-40 Lysis Buffer 10%
22040073-1	Bio-WORLD	100 mL	EUR 88.65

NP-40 Lysis Buffer 10%
22040073-2	Bio-WORLD	500 mL	EUR 212.1

NP-40 Lysis Buffer 10%
22040073-3	Bio-WORLD	1 L	EUR 339.83

NP-40 Lysis Buffer No Salt
22040046-1	Bio-WORLD	250 mL	EUR 32.55

NP-40 Lysis Buffer No Salt
22040046-2	Bio-WORLD	500 mL	EUR 63.5

NP-40 Lysis Buffer No Salt
22040046-3	Bio-WORLD	1 L	EUR 96.98

NP-40 Lysis Buffer Low Salt
22040045-1	Bio-WORLD	250 mL	EUR 38.72

NP-40 Lysis Buffer Low Salt
22040045-2	Bio-WORLD	500 mL	EUR 63.5

NP-40 Lysis Buffer Low Salt
22040045-3	Bio-WORLD	1 L	EUR 96.98

MES Lysis Buffer with NP-40
41320095-1	Bio-WORLD	100 mL	EUR 33.33

MES Lysis Buffer with NP-40
41320095-2	Bio-WORLD	250 mL	EUR 52.73

MES Lysis Buffer with NP-40
41320095-3	Bio-WORLD	500 mL	EUR 85.01

MES Lysis Buffer with NP-40
41320095-4	Bio-WORLD	1 L	EUR 106.79

NP-40 Lysis Buffer High Salt
22040044-1	Bio-WORLD	250 mL	EUR 34.28

NP-40 Lysis Buffer High Salt
22040044-2	Bio-WORLD	500 mL	EUR 53.25

NP-40 Lysis Buffer High Salt
22040044-3	Bio-WORLD	1 L	EUR 98.27

HEPES Lysis Buffer with NP-40
40820045-1	Bio-WORLD	100 mL	EUR 26.26

HEPES Lysis Buffer with NP-40
40820045-2	Bio-WORLD	250 mL	EUR 51.85

HEPES Lysis Buffer with NP-40
40820045-3	Bio-WORLD	500 mL	EUR 97.65

HEPES Lysis Buffer with NP-40
40820045-4	Bio-WORLD	1 L	EUR 180.9

MES Lysis Buffer with NP-40 2X
41320096-1	Bio-WORLD	125 mL	EUR 42.19

MES Lysis Buffer with NP-40 2X
41320096-2	Bio-WORLD	250 mL	EUR 73.4

MES Lysis Buffer with NP-40 2X
41320096-3	Bio-WORLD	500 mL	EUR 98.19

MES Lysis Buffer with NP-40 2X
41320096-4	Bio-WORLD	1 L	EUR 145.03

HEPES Lysis Buffer with NP-40, 2X
40820046-1	Bio-WORLD	125 mL	EUR 42.09

HEPES Lysis Buffer with NP-40, 2X
40820046-2	Bio-WORLD	250 mL	EUR 59.03

HEPES Lysis Buffer with NP-40, 2X
40820046-3	Bio-WORLD	500 mL	EUR 97.65

HEPES Lysis Buffer with NP-40, 2X
40820046-4	Bio-WORLD	1 L	EUR 180.71

PIPES Lysis Buffer with NP-40 2X
41620175-1	Bio-WORLD	125 mL	EUR 42.09

PIPES Lysis Buffer with NP-40 2X
41620175-2	Bio-WORLD	250 mL	EUR 78.34

PIPES Lysis Buffer with NP-40 2X
41620175-3	Bio-WORLD	500 mL	EUR 105.44

PIPES Lysis Buffer with NP-40 2X
41620175-4	Bio-WORLD	1 L	EUR 202.68

HEPES Cell Lysis buffer with NP-40
H5100-100	GenDepot	100ml	EUR 141.6

NP-40 Lysis Buffer with Glycerol 2X
22040065-1	Bio-WORLD	125 mL	EUR 35.43

NP-40 Lysis Buffer with Glycerol 2X
22040065-2	Bio-WORLD	250 mL	EUR 58.64

NP-40 Lysis Buffer with Glycerol 2X
22040065-3	Bio-WORLD	500 mL	EUR 94.44

PIPES Lysis Buffer with NP-40, pH 7.0
41620174-1	Bio-WORLD	100 mL	EUR 26.07

PIPES Lysis Buffer with NP-40, pH 7.0
41620174-2	Bio-WORLD	250 mL	EUR 53.29

PIPES Lysis Buffer with NP-40, pH 7.0
41620174-3	Bio-WORLD	500 mL	EUR 78.22

PIPES Lysis Buffer with NP-40, pH 7.0
41620174-4	Bio-WORLD	1 L	EUR 167.29

Lysis Buffer
abx098984-LysisBuffer120ml	Abbexa	Lysis Buffer 1 (20 ml)	EUR 184.8

Lysis Buffer
abx098984-LysisBuffer3100ml	Abbexa	Lysis Buffer 3 (100ml)	EUR 276

Lysis Buffer
abx098984-LysisBuffer420ml	Abbexa	Lysis Buffer 4 (20 ml)	EUR 184.8

Lysis Buffer
abx098984-100l	Abbexa	100 µl	EUR 93.75

Lysis Buffer
abx098984-1ml	Abbexa	1 ml	EUR 93.75

Lysis Buffer
abx098984-200l	Abbexa	200 µl	EUR 93.75

Lysis Buffer
MBS2090451-100mLLysisBuffer1	MyBiosource	100mLLysisBuffer1	EUR 145

Lysis Buffer
MBS2090451-20mLLysisBuffer1	MyBiosource	20mLLysisBuffer1	EUR 115

Lysis Buffer
MBS2090451-20mLLysisBuffer2	MyBiosource	20mLLysisBuffer2	EUR 115

Lysis Buffer
MBS2090451-20mLLysisBuffer3	MyBiosource	20mLLysisBuffer3	EUR 115

Lysis Buffer
MBS2090451-20mLLysisBuffer4	MyBiosource	20mLLysisBuffer4	EUR 115

Lysis Buffer
TRI-C77M101	TRI Biotech	20mL	EUR 126

Red Blood Cell Lysis Buffer,or ACK Lysis Buffer
ETF3702	EnoGene	120ml	EUR 24

Red Blood Cell Lysis Buffer, or ACK Lysis Buffer
MBS8579525-120mL	MyBiosource	120mL	EUR 120

Red Blood Cell Lysis Buffer, or ACK Lysis Buffer
MBS8579525-5x120mL	MyBiosource	5x120mL	EUR 390

IP Lysis Buffer
AR0107	BosterBio	100mL	EUR 121.2

WB Lysis Buffer
BMP2010-100mL	Abbkine	100 mL	EUR 59
Description: WB Lysis Buffer

WB Lysis Buffer
BMP2010-each	Abbkine	each	Ask for price

WB Lysis Buffer
BMP2010-Null	Abbkine	Null	Ask for price

WB Lysis Buffer
MBS9719256-100mL	MyBiosource	100mL	EUR 130

WB Lysis Buffer
MBS9719256-5x100mL	MyBiosource	5x100mL	EUR 585

RBC Lysis Buffer
18-448	Genesee Scientific	125 mL/Unit	EUR 51.81
Description: Lysis of Red Blood Cells

RBC Lysis Buffer
18-449	Genesee Scientific	250 mL/Unit	EUR 94.36
Description: Lysis of Red Blood Cells

RBC LYSIS BUFFER
IB47620	IBI Scientific	135ML	EUR 34.24

RBC LYSIS BUFFER
IB47621	IBI Scientific	200ML	EUR 50.69

RBC LYSIS BUFFER
IB47622	IBI Scientific	500ML	EUR 97.24

Tail Lysis Buffer
06169-95	NACALAI TESQUE	500ML	EUR 61.6

Cell Lysis Buffer
1067-100	Biovision	each	EUR 196.8

Cell Lysis Buffer
1067-400	Biovision	each	EUR 352.8

Cell Lysis Buffer
AR0103	BosterBio	100mL (The kit contains sufficient lysis buffer for 200 cell pellet fractions containing 5x 106 cells each)	EUR 145.2

RIPA Lysis Buffer
AR0105	BosterBio	50 mL	EUR 90

STET Lysis Buffer
61600	Sisco Laboratories	500 ml	EUR 28.5
Description: Part B

Cell Lysis Buffer
GR103003	Genorise Scientific	200 mL	EUR 54

Cell Lysis Buffer
TBS5001	Tribioscience	40ml	EUR 55

RIPA Lysis Buffer
E0295-01	EURx	50ml	EUR 45.78
Description: RIPA (Radioimmunoprecipitation Assay) Buffer for general lysis of cells

RIPA Lysis Buffer
E0295-02	EURx	200ml	EUR 203.83
Description: RIPA (Radioimmunoprecipitation Assay) Buffer for general lysis of cells

RIPA Lysis Buffer
AR0105-100	BosterBio	100ml	EUR 55
Description: RIPA Lysis Buffer is a complete cell lysis solution reagent used for rapid and efficient total cell lysis and solubilization of proteins from both adherent and suspension cultured mammalian cells, effectively extracting cytoplasmic, nuclear and membrane proteins. RIPA lysis buffer is highly compatible with various downstream protein analysis applications.

RIPA Lysis Buffer
MBS651650-100mL	MyBiosource	100mL	EUR 780

RIPA Lysis Buffer
MBS651650-10mL	MyBiosource	10mL	EUR 195

RIPA Lysis Buffer
MBS651650-25mL	MyBiosource	25mL	EUR 320

RIPA Lysis Buffer
MBS651650-50mL	MyBiosource	50mL	EUR 500

RIPA Lysis Buffer
MBS651650-5x100mL	MyBiosource	5x100mL	EUR 3365

RIPA Lysis Buffer
MBS1753872-100mL	MyBiosource	100mL	EUR 155

RIPA Lysis Buffer
MBS1753872-5x100mL	MyBiosource	5x100mL	EUR 540

RIPA Lysis Buffer
MBS2557000-100mL	MyBiosource	100mL	EUR 135

RIPA Lysis Buffer
MBS2557000-20mL	MyBiosource	20mL	EUR 95

RIPA Lysis Buffer
MBS2557000-50mL	MyBiosource	50mL	EUR 125

RIPA Lysis Buffer
MBS2557000-5x100mL	MyBiosource	5x100mL	EUR 555

Phage Lysis Buffer
30629559-1	Bio-WORLD	100 mL	EUR 30.3

Phage Lysis Buffer
30629559-2	Bio-WORLD	500 mL	EUR 41.52

Phage Lysis Buffer
30629559-3	Bio-WORLD	1 L	EUR 55.68

Hypotonic Lysis Buffer
22050012-1	Bio-WORLD	100 mL	EUR 46.28

Denaturing Lysis Buffer
22040027-1	Bio-WORLD	250 mL	EUR 35.5

Denaturing Lysis Buffer
22040027-2	Bio-WORLD	500 mL	EUR 56.21

Cell Lysis Buffer, 100ML
X050-100ML	Arbor Assays	100ML	EUR 70

WB (IP) Lysis Buffer
BMP2020-100mL	Abbkine	100 mL	EUR 59
Description: WB (IP) Lysis Buffer

WB (IP) Lysis Buffer
BMP2020-each	Abbkine	each	Ask for price

WB (IP) Lysis Buffer
BMP2020-Null	Abbkine	Null	Ask for price

WB (IP) Lysis Buffer
MBS9719334-100mL	MyBiosource	100mL	EUR 130

WB (IP) Lysis Buffer
MBS9719334-5x100mL	MyBiosource	5x100mL	EUR 585

10×ACK Lysis Buffer
E-CK-A105-100mL	Elabscience Biotech	100 mL	EUR 14

10×ACK Lysis Buffer
E-CK-A105-200mL	Elabscience Biotech	200 mL	EUR 20

10×ACK Lysis Buffer
E-CK-A105-500mL	Elabscience Biotech	500 mL	EUR 45

10×ACK Lysis Buffer
E-CK-A105-each	Elabscience Biotech	each	Ask for price

Tail Lysis Buffer 1
10450042-1	Bio-WORLD	250 mL	EUR 44.22

Tail Lysis Buffer 1
10450042-2	Bio-WORLD	500 mL	EUR 66.89

Tail Lysis Buffer 2
10450044-1	Bio-WORLD	250 ml	EUR 33.33

Tail Lysis Buffer 2
10450044-2	Bio-WORLD	500 ml	EUR 55.65

Tail Lysis Buffer 3
10450046-1	Bio-WORLD	250 ml	EUR 33.33

Tail Lysis Buffer 3
10450046-2	Bio-WORLD	500 ml	EUR 66.89

Tail Lysis Buffer 4
10450048-1	Bio-WORLD	500 ml	EUR 55.77

10X RBC Lysis Buffer
MBS697186-100mL	MyBiosource	100mL	EUR 155

10X RBC Lysis Buffer
MBS697186-5x100mL	MyBiosource	5x100mL	EUR 650

10x ACK Lysis Buffer
MBS2567124-100mL	MyBiosource	100mL	EUR 85

10x ACK Lysis Buffer
MBS2567124-200mL	MyBiosource	200mL	EUR 90

10x ACK Lysis Buffer
MBS2567124-500mL	MyBiosource	500mL	EUR 110

10x ACK Lysis Buffer
MBS2567124-5x500mL	MyBiosource	5x500mL	EUR 485

ChIP Lysis Buffer III
10450058-1	Glycomatrix	100 mL	EUR 36.85

ChIP Lysis Buffer III
10450058-2	Glycomatrix	250 ml	EUR 54.54

ChIP SDS Lysis Buffer
22050031-1	Bio-WORLD	10 mL	Ask for price
Description: Chromatin Immunoprecipitation (ChIP) assays

ChIP SDS Lysis Buffer
22050031-2	Bio-WORLD	25 mL	Ask for price
Description: Chromatin Immunoprecipitation (ChIP) assays

CHAPS Lysis Buffer 1X
22050006-1	Bio-WORLD	250 mL	EUR 51.7

CHAPS Lysis Buffer 1X
22050006-2	Bio-WORLD	500 mL	EUR 82.5

CHAPS Lysis Buffer 2X
22050008-1	Bio-WORLD	25 mL	EUR 46

CHAPS Lysis Buffer 2X
22050008-2	Bio-WORLD	50 mL	EUR 75.74

CHAPS Lysis Buffer 2X
22050008-3	Bio-WORLD	100 mL	EUR 109.98

RIPA Lysis Buffer (Weak)
abx090626-100ml	Abbexa	100 ml	EUR 260.4

Weak RIPA Lysis Buffer
EZPS05-1	Shanghai WSHT Biotechnology	100mL	EUR 13.8

RIPA Lysis Buffer (Weak)
abx090626-100l	Abbexa	100 µl	EUR 150

RIPA Lysis Buffer (Weak)
abx090626-1ml	Abbexa	1 ml	Ask for price

RIPA Lysis Buffer (Weak)
abx090626-200l	Abbexa	200 µl	Ask for price

Plus RIPA Lysis Buffer
AR0102-100	BosterBio	100ml	EUR 65
Description: Plus RIPA Lysis Buffer is a complete cell lysis solution reagent used for rapid and efficient total cell lysis and solubilization of proteins from both adherent and suspension cultured mammalian cells, effectively extracting cytoplasmic, nuclear and membrane proteins. RIPA lysis buffer is highly compatible with various downstream protein analysis applications.

Plus RIPA Lysis Buffer
MBS1753871-100mL	MyBiosource	100mL	EUR 160

Plus RIPA Lysis Buffer
MBS1753871-5x100mL	MyBiosource	5x100mL	EUR 570

RIPA Lysis Buffer (Weak)
MBS355476-100mL	MyBiosource	100mL	EUR 210

RIPA Lysis Buffer (Weak)
MBS355476-5x100mL	MyBiosource	5x100mL	EUR 640

CHAPS Cell Lysis Buffer
C2000-100	GenDepot	100ml	EUR 165.6

CHAPS Cell Lysis Buffer
C2000-500	GenDepot	500ml	EUR 400.8

5X Passive Lysis Buffer
99912	Biotium	30ML	EUR 31
Description: N/A

5X Passive Lysis Buffer
99912-1	Biotium	EA	EUR 31

1X Protein Lysis Buffer
G032	ABM	5.0 ml (5 x 1.0ml)	EUR 40

RIPA Lysis Buffer (Strong)
abx090624-100ml	Abbexa	100 ml	EUR 260.4

RIPA Lysis Buffer (Medium)
abx090625-100ml	Abbexa	100 ml	EUR 260.4

RIPA Lysis Buffer (Strong)
E-BC-R327-100mL	Elabscience Biotech	100mL	EUR 80

RIPA Lysis Buffer (Strong)
E-BC-R327-20mL	Elabscience Biotech	20mL	EUR 25

RIPA Lysis Buffer (Strong)
E-BC-R327-50mL	Elabscience Biotech	50mL	EUR 60

RIPA Lysis Buffer (Strong)
E-BC-R327-each	Elabscience Biotech	each	Ask for price

Strong RIPA Lysis Buffer
EZPS03-1	Shanghai WSHT Biotechnology	100mL	EUR 15

Medium RIPA Lysis Buffer
EZPS04-1	Shanghai WSHT Biotechnology	100mL	EUR 14.4

RIPA Lysis Buffer (Strong)
HY-K1001	MedChemExpress	100 mL	EUR 176.4

Formic Acid Lysis Buffer
22050063-1	Bio-WORLD	250 mL	EUR 37.67

RIPA Lysis Buffer (Strong)
abx090624-100l	Abbexa	100 µl	EUR 150

RIPA Lysis Buffer (Strong)
abx090624-1ml	Abbexa	1 ml	Ask for price

RIPA Lysis Buffer (Strong)
abx090624-200l	Abbexa	200 µl	Ask for price

RIPA Lysis Buffer (Medium)
abx090625-100l	Abbexa	100 µl	EUR 150

RIPA Lysis Buffer (Medium)
abx090625-1ml	Abbexa	1 ml	Ask for price

RIPA Lysis Buffer (Medium)
abx090625-200l	Abbexa	200 µl	Ask for price

RIPA Lysis Buffer (Strong)
MBS355478-100mL	MyBiosource	100mL	EUR 210

RIPA Lysis Buffer (Strong)
MBS355478-5x100mL	MyBiosource	5x100mL	EUR 640

RIPA Lysis Buffer (Medium)
MBS355485-100mL	MyBiosource	100mL	EUR 210

RIPA Lysis Buffer (Medium)
MBS355485-5x100mL	MyBiosource	5x100mL	EUR 640

Lysis Buffer for Bacillus
22040042-1	Bio-WORLD	100 mL	EUR 102.44

Caspase Cell Lysis Buffer
MBS565711-30mL	MyBiosource	30mL	EUR 150

Caspase Cell Lysis Buffer
MBS565711-5x30mL	MyBiosource	5x30mL	EUR 525

Exosomal Protein Lysis Buffer
P200P,-part-of-P200	101Bio	-	Ask for price

Exosomal Protein Lysis Buffer
P200P	101Bio	2 ml	EUR 339

C to C Lysis Buffer
abx298007-5ml	Abbexa	5 ml	EUR 343.2

10 x Cell Lysis Buffer
GR103003x10	Genorise Scientific	200 mL	EUR 118

Tail Lysis Buffer 1 2X
10450043-1	Bio-WORLD	250 ml	EUR 66.89

Evenzo, ongeacht de populariteit van angiotensine-veranderend enzym 2 (ACE2) omdat de receptor voor extreem acuut respiratoir syndroom coronavirus 2 (SARS CoV-2) en de functie van ACE2 bij longschade; er zijn tegenstrijdige resultaten bij het gebruik van angiotensine veranderende enzym (ACE) -remmers en angiotensine-receptorblokkers (ARB) bij deze patiënten.

Het beheer van diabetespatiënten in het geval van mobiliteitsbeperkingen vormt een aantal uitdagingen en nieuwe benaderingen zoals telegeneeskunde kunnen nuttig zijn. Er moet extra onderzoek worden gedaan naar het pure beloop van COVID-19 bij patiënten met diabetes en om de persoon, regionale en etnische verschillen in ziekteprevalentie en beloop te begrijpen.